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Test Code P2Y12 P2Y12 Platelet Reactivity Unit (PRU)

Important Note

Contact performing laboratory to obtain proper collection tubes (Greiner Brand).

SPECIAL INSTRUCTIONS: A waste tube must be collected before Greiner tubes are collected.  The collection needle must be 21 gauge or larger.

Specimens cannot be transported through the pneumatic tube system or in a vehicle.

Performing Laboratory

Memorial Hospital Laboratory- Automated Procedures  304-388-5953       
General Hospital Laboratory 304-388-6244

Specimen Requirements

Whole Blood- Greiner Brand Sodium Citrate Tubes

Draw 2 full, tubes by “clean” venipuncture (no excessive trauma).

Immediately after draw, invert tubes several times to mix blood with additive.

Specimen Rejection

  • Improperly labeled, collected, stored, and transported
  • Quantity not sufficient
  • Hemolyzed 
  • Clotted
  • Specimen sent through the pneumatic tube system or vehicle.

Storage and Stability

Room temperature 4 hours

Reference Values

182-335 PRU

 

Interpretation

Therapeutic monitoring: PRU results < 194 are indicitive of anti-platelet effect.

Cardiac/Anti-thrombotic: PRU results < 208 are associated with decreased complications post PCI (e.g. GRAVITAS, Circulation 124:1132-1137, 2011)

<95 PRU indicated no additional protection from cardiovascular events, but it significantly increased risk of bleeding.

Methodology

Photo-optical

 

This test measures platelet reactivity in response to activation of the P2Y12 receptor (P2Y12 reaction units/PRU).  PRU is decreased by P2Y12 ADP receptor inhibitors (Clopidogrel, Effient, Brilanta, Ticlid).

Days Test Set Up and Turnaround

Monday through Sunday, Continuously

AM Collection Expected by 9AM same day
Routine Expected within 24 hrs
Stat Expected within 1 hr
Timed Expected results are test dependant

CPT Coding

85576